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Technical Profile

Radiotherapy 4.0

Ideal Therapy Radiation

Energetic heavy ions have characteristics of a high ionization density and a high relative biological effectiveness (RBE), culminating in a sharp maximum around the so-called Bragg peak. The peak energy depositions can be achieved three-dimensionally with a minimal risk of harming surrounding healthy tissue. The biological efficiency of heavy ions is superior to that of conventional X-ray and Gamma ray radiotherapies, even in the condition of hypoxia (lack of oxygen). Radio-resistant cancers that have a high repairing capability against photon irradiation become sensitive to the treatment with heavy ions. This feature makes it possible to kill growing and dormant (inactive) cancer cells using heavy-ion therapy. Heavy ions also show less fractionation dependence than conventional radiation treatment, which leads to faster treatment and less stress for patients. In case of heavy ion, the dose localization is better due to its decreased scattering compared to protons, especially for the distant part of a larger cancer. In addition, the RBE is higher for heavy ions than that for protons. Taking these favorable characteristics and together with the painlessness and limited impact on the patient's overall constitution, heavy-ion beams are considered to be the most optimal radiation for cancer treatment in the field of radiotherapy, and therefore heavy-ion cancer therapy is attracting growing interest all over the world.

Physical and Biological Advantages

Energy deposition of carbon ion beams to sharp maximum at the end of the range (Bragg peak)

Less energy deposited into the healthy tissue surrounding the target tissue, causing minimal side effects

High relative biological effect (RBE) causing DNA double strand breaks

Low oxygen enhancement ratio, suitable for treatment of hypoxic tumors

Small beam size for high precision treatment

3D scanning and real-time monitoring

Particularly suitable for the treatment of refractory tumors

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